Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices
نویسندگان
چکیده
منابع مشابه
Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices.
Extracellular matrices (ECMs) are complex materials, containing at least dozens of different macromolecules that are assembled together, thus complicating their optimization towards applications in 3D cell culture or tissue engineering. The natural complexity of ECMs has limited cell-matrix investigations predominantly to experiments where only one matrix component is adjusted at a time, making...
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Tissue engineering may provide an alternative to organ and tissue transplantation, both of which suffer from a limitation of supply. Cell transplantation using biodegradable synthetic extracellular matrices offers the possibility of creating completely natural new tissues and so replacing lost or malfunctioning organs or tissues. Synthetic extracellular matrices fabricated from biocompatible, b...
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PURPOSE First, to confirm that corneal endothelial cells in the confluent state have the capability to form cellular covering. Second, to establish a method to study the combined effect of extracellular matrices (ECMs) and growth factors on the biological response in corneal endothelial cells in culture. METHODS Bovine corneal endothelial cells were cultured inside a cylinder set on a plastic...
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ژورنال
عنوان ژورنال: Integrative Biology
سال: 2011
ISSN: 1757-9694,1757-9708
DOI: 10.1039/c0ib00112k